
Toenail Alterations
Toenail onychomycosis (fungal nail infection) and chronic venous disease are significant health problems and the incidence of both diseases increase with advancing age and can reduce patient’s quality of life.
The fungal infection is more common in toenails than in fingernails. The prevalence is increasing due to aging, life-style changes and with diabetes mellitus.
Studies have showed that fungal infection is more common in patients with chronic venous disease.
The reason for skin and toenail abnormalities in chronic venous disease is complex. In chronic venous disease there is venous hypertension (high pressure) causes a decrease in blood flow through the small blood vessels and decrease number and leading to abnormal changes in the walls of the small blood vessels. Decreased blood flow and nutrient deficiency are the most likely reason for increased cell death and decreased tissue regeneration. The nail growth is slower, the skin becomes dry and nail becomes brittle and immune response decreases.
If there are toe nail abnormalities, nail specimen must be obtained and send for fungal examination.
Onychomycosis was more frequent in patients with more advanced stage of chronic venous disease.

Other non-fungal toe nail alterations are:
-
Nail discoloration
-
Onycholysis, or nail lifting, is the separation of the fingernail or toenail from the nail bed. Nail lifting creates space under the nail that gathers dirt and debris. When water gets under the nail, bacteria and yeast can cause the area to become infected. Nail lifting is most often caused by some sort of injury to the nail. The portion of the nail that has separated from the nail bed cannot reattach itself, so the goal is to allow new healthy nail growth, which may take several months.
-
Thickening of the nail
-
Nail plate splitting
-
Subungual hyperkeratosis
-
Nail desquamation
Studies confirmed high frequency of toe nail alterations in patients with chronic venous insufficiency. Non-fungal toenail deformations can be contributed to dysfunction in circulation which also can lead to dry skin and hair loss on the lower legs.
Moreover, non-fungal nail deformations and fungal infection can occur at the same time with chronic venous insufficiency.
Previously damaged nails due to chronic venous disease are more predisposed to fungal infection. Toenail alterations were present in a high proportion of patients with chronic venous disease.

Toenails and Chronic Venous Insufficiency
In the intricate landscape of human health, seemingly unrelated body parts can reveal profound insights into underlying medical conditions. Toenails, often overlooked as mere keratin structures, actually serve as remarkable indicators of potential vascular health issues, particularly chronic venous insufficiency (CVI). This comprehensive exploration will illuminate the surprising connections between these small yet significant bodily markers.
Understanding Toenail Changes
Chronic venous insufficiency represents a complex circulatory disorder where leg veins struggle to efficiently return blood to the heart. Consequently, this dysfunction manifests through various physiological changes, with toenails emerging as unexpected diagnostic witnesses. Patients experiencing CVI often demonstrate distinctive toenail transformations that medical professionals carefully observe.
Initially, these changes might appear subtle. Toenails may develop unusual discolorations, ranging from yellowish-brown hues to more pronounced pigmentation variations. Moreover, structural modifications become increasingly apparent, with nails potentially becoming thicker, more brittle, or displaying irregular growth patterns.
The intricate relationship between toenails and chronic venous insufficiency stems from compromised blood circulation. When venous return becomes impaired, peripheral tissues—including toenails—experience reduced oxygen and nutrient supply. This physiological disruption triggers a cascade of observable alterations that astute healthcare practitioners recognize as potential warning signs.
Notably, patients with advanced CVI might experience significant toenail changes, including:
-
Increased nail thickness
-
Longitudinal ridging
-
Decreased nail flexibility
-
Slower growth rates
-
Potential fungal infections due to compromised circulation
Diagnostic Implications: Beyond Cosmetic Observations
Healthcare professionals increasingly recognize toenails as valuable diagnostic windows. These seemingly mundane structures offer critical insights into an individual's vascular health, potentially signalling underlying circulatory challenges before more severe symptoms manifest.
Researchers have discovered that specific toenail characteristics—such as colour, texture, and growth patterns—can correlate directly with venous system functionality. By carefully examining these minute details, medical experts can develop more comprehensive assessment strategies for chronic venous insufficiency.
Prevention and Proactive Management
Understanding the correlation between toenails and chronic venous insufficiency empowers individuals to adopt proactive health strategies. Regular foot examinations, maintaining proper circulation through exercise, and consulting healthcare professionals when unusual toenail changes occur can significantly mitigate potential complications.
Conclusion: Listening to Your Body's Silent Messengers
Toenails represent more than mere aesthetic appendages—they are sophisticated biological indicators capable of communicating complex health narratives. By paying close attention to these subtle signals, individuals can potentially identify and address chronic venous insufficiency at earlier, more manageable stages.


